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Blood 17 : — Article history Submitted:. Connected Content. This is a companion to: Advances in the treatment of hematologic malignancies using immunoconjugates.
This is a companion to: Immunotoxins for leukemia. Cite Icon Cite. Figure 1. View large Download PPT. Figure 2. Table 1 CAR T-cell trials in hematologic malignancies.
Signaling domain. Other genes. Cytokine support. Number of patients. Persistence peak and duration. View Large. Gene transfer.
CAR signaling domain. The online version of this article contains a data supplement. The authors thank Anne Chew and Bruce Levine for constructive comments.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Search ADS. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma.
Anti-CDchimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.
T cell activation by recombinant FcepsilonRI gamma-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Sleeping beauty system to redirect T-cell specificity for human applications.
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci Transl Med.
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.
IL-7 and IL allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. CDspecific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and BB domains: pilot clinical trial results.
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients.
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation.
Infusion of donor-derived CDredirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study.
T cell immunotherapy: optimizing trial design. Paper presented at the Scientific Symposium, September , Bethesda, MD.
Manufacture of clinical-grade CDspecific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells.
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
Donor-derived CDtargeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Safety and persistence of adoptively transferred autologous CDtargeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias.
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.
CDtargeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
Chimeric receptors containing CD signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.
HLH Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis.
Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL.
Understanding the immunodeficiency in chronic lymphocytic leukemia: potential clinical implications. The microenvironment in mature B-cell malignancies: a target for new treatment strategies.
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia.
Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes.
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy.
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Tumor-targeted T cells modified to secrete IL eradicate systemic tumors without need for prior conditioning.
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CDspecific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
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